HFE Gene Variants Affect Iron in the Brain

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HFE gene variants affect iron in the brain.

Iron accumulation in the brain and increased oxidative stress are consistent observations in many neurodegenerative diseases. Thus, we have begun examination into gene mutations or allelic variants that could be associated with loss of iron homeostasis. One of the mechanisms leading to iron overload is a mutation in the HFE gene, which is involved in iron metabolism. The 2 most common HFE gene ...

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HFE gene variants and iron-induced oxygen radical generation in idiopathic pulmonary fibrosis.

In idiopathic pulmonary fibrosis (IPF), lung accumulation of excessive extracellular iron and macrophage haemosiderin may suggest disordered iron homeostasis leading to recurring microscopic injury and fibrosing damage. The current study population comprised 89 consistent IPF patients and 107 controls. 54 patients and 11 controls underwent bronchoalveolar lavage (BAL). Haemosiderin was assessed...

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HFE gene variants, iron, and lipids: a novel connection in Alzheimer’s disease

Iron accumulation and associated oxidative stress in the brain have been consistently found in several neurodegenerative diseases. Multiple genetic studies have been undertaken to try to identify a cause of neurodegenerative diseases but direct connections have been rare. In the iron field, variants in the HFE gene that give rise to a protein involved in cellular iron regulation, are associated...

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Iron-related gene variants and brain iron in multiple sclerosis and healthy individuals

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Iron overload in HFE C282Y heterozygotes at first genetic testing: a strategy for identifying rare HFE variants.

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ژورنال

عنوان ژورنال: The Journal of Nutrition

سال: 2011

ISSN: 0022-3166,1541-6100

DOI: 10.3945/jn.110.130351